Your Treatment for prostate cancer. Reimagined.

Today, localized therapy options are limited in providing surgeons and patients with a customizable and confident treatment. Most options come with substantial trade-offs, dictating the ability to treat effectively. The NanoKnife System reimagines localized therapy through its unique mechanism of action, improving precision, expanding versatility, and increasing preservation, thus giving your urologist the control to tailor treatments with confidence.


The NanoKnife System gives your urologist the ability to sculpt and control the targeted zone through a variety of electrode configurations. Irreversible electroporation (IRE) effectively destroys the cancerous tissue and gives precise treatment margins resulting in confident treatment coverage for the procedure.


The procedure spares vital structures by retaining the structural integrity of the targeted tissue. The delivery of non-thermal energy allows for the preservation of the extra-cellular matrix, facilitating post-ablation, histological and functional tissue regeneration.


Multiple electrode configurations, coupled with a unique mechanism of action, allow the device to be used in all segments of an organ to optimize treatment delivery. Electrodes can be confidently placed near vital structures, maximizing the ability to personalize treatment to the patient’s anatomy.


Blazevski A, Amin A, Scheltema MJ, Balakrishnan A, Haynes AM, Barreto D, Cusick T, Thompson J, Stricker PD. Focal ablation of apical prostate cancer lesions with irreversible electroporation (IRE). World J Urol. 2020 Jun 2. doi: 10.1007/s00345-020-03275-z. Epub ahead of print. PMID: 32488359.

Scheltema MJ, Chang JI, van den Bos W, Gielchinsky I, Nguyen TV, Reijke TM, Siriwardana AR, Böhm M, de la Rosette JJ, Stricker PD. Impact on genitourinary function and quality of life following focal irreversible electroporation of different prostate segments. Diagn Interv Radiol. 2018 Sep;24(5):268-275. doi: 10.5152/dir.2018.17374. PMID: 30211680; PMCID: PMC6135060.

Li W, Fan Q, Ji Z, Qiu X, Li Z. The effects of irreversible electroporation (IRE) on nerves. PLoS One. 2011 Apr 14;6(4):e18831. doi: 10.1371/journal.pone.0018831. PMID: 21533143; PMCID: PMC3077412.

Lee EW, Thai S, Kee ST. Irreversible electroporation: a novel image-guided cancer therapy. Gut Liver. (2010);4(SUPPL. 1):99–104. doi: 10.5009/gnl.2010.4.S1.S99

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