The Skene's glands, also called paraurethral/periurethral glands, are two glands the size of a corn grain located around the urethra (the channel through which urine exits). However, their orifices are the same thickness as a pin. At the time of orgasm, their role is to secrete a fluid that can be very clear to slightly white, with varying thickness. The volume emitted during ejaculation varies; in general, the quantity is very small and this secretion goes unnoticed. The Skene's glands are the equivalent of the prostate in men.

The Skene's glands can become infected or inflamed. In both cases, the result can cause symptoms in the urinary tract similar to those of a urinary infection. Abscesses and cysts within these glands can also trigger such symptoms and become uncomfortable for the woman.